GPIHBP1: Lipoprotein Lipase's Ticket to Ride
نویسندگان
چکیده
منابع مشابه
Neurotrophins: A Ticket to Ride for BDNF
The secretion of BDNF from neurons is under activity-dependent control: this is crucial for the formation of appropriate synaptic connections during development and for learning and memory in adults. New evidence shows that interaction between a motif in the tertiary structure of BDNF and the sorting receptor carboxypeptidase E directs this neurotrophin to the regulated secretory pathway.
متن کاملToxo has a ticket to ride
Lethal shock is subverted by crippling a family of G proteins in endothelial cells, according to Korhonen and colleagues on page 411. Bee stings or other allergens can cause anaphylactic shock in severely allergic individuals by triggering mast cell activation and the release of anaphylactic mediators like histamine and platelet activating factor (PAF). At high enough levels, these mediators ca...
متن کاملGPIHBP1 missense mutations often cause multimerization of GPIHBP1 and thereby prevent lipoprotein lipase binding.
RATIONALE GPIHBP1, a GPI-anchored protein of capillary endothelial cells, binds lipoprotein lipase (LPL) in the subendothelial spaces and shuttles it to the capillary lumen. GPIHBP1 missense mutations that interfere with LPL binding cause familial chylomicronemia. OBJECTIVE We sought to understand mechanisms by which GPIHBP1 mutations prevent LPL binding and lead to chylomicronemia. METHODS...
متن کاملTicket to Ride: tRNA-Related Sequences and Systemic Movement of mRNAs.
Movement of macromolecules through the plant phloem provides a mechanism for long-distance signaling that plants use in development, disease resistance, and other adaptive responses (reviewed in Spiegelman et al., 2013). For example, full-length RNAs, such as the Arabidopsis thaliana GIBBERELLIC ACID INSENSITIVE, and potato (Solanum tuberosum) BEL5 mRNAs, and small RNAs, including numerous micr...
متن کاملMutations in lipoprotein lipase that block binding to the endothelial cell transporter GPIHBP1.
GPIHBP1, a glycosylphosphatidylinositol-anchored protein of capillary endothelial cells, shuttles lipoprotein lipase (LPL) from subendothelial spaces to the capillary lumen. An absence of GPIHBP1 prevents the entry of LPL into capillaries, blocking LPL-mediated triglyceride hydrolysis and leading to markedly elevated triglyceride levels in the plasma (i.e., chylomicronemia). Earlier studies hav...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell Metabolism
سال: 2010
ISSN: 1550-4131
DOI: 10.1016/j.cmet.2010.06.005